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aortic sac
The aortic sac or aortic bulb〔Annalisa Berta, James L. Sumich, Kit M. Kovacs. (Marine Mammals: Evolutionary Biology ). Academic Press, 2006; page 240.〕 is a dilated structure in mammalian embryos, lined by endothelial cells located just above (distal to) the truncus arteriosus. It is the primordial vascular channel from which the aortic arches arise (and eventually the dorsal aortae) and is homologous to the ventral aorta of gill-bearing vertebrates. Genes ''dHAND'' and ''eHAND'' are expressed during the development of the aortic bulb and the arteries which arise from it.〔Richard P. Harvey, Nadia Rosenthal (ed). (Heart Development ). Gulf Professional Publishing, 1999; page 150-151.〕 The protein encoded by these genes belong to the basic helix-loop-helix family of transcription factors. == References ==
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